Books of exegesis explain that a “loss of fruits” [as outlined in Surah al-Baqarah, Ch.2: V.156] also implies a person’s children and the loss of one’s efforts.
For example, one’s effort to acquire knowledge; one’s effort to succeed in business; the efforts of a farmer. The loss of such efforts is a terrible misfortune. Man is forever concerned with attaining success.
However, ultimately, the knowledge of God and His wisdom demands at times that people fail, or that their crops do not bring harvest, or that they are unsuccessful in business.
(Hazrat Mirza Ghulam Ahmadas, Malfuzat, Vol. 1, p. 250)